Introducing a new method for determining water content in lactose using NIR spectroscopy
Lactose is an indispensable ingredient in the pharmaceutical industry, but excessive moisture content can lead to significant production challenges. Near-Infrared Spectroscopy (NIRS) offers a fast, precise, and innovative method for determining water content in lactose, providing results in just a few seconds without the need for reagents or time-consuming procedures.
Approximately 60% to 70% of pharmaceutical dosage forms containing it. Due to its properties, lactose is commonly used as a filler in tablets, as a binder to enhance tablet strength, and to aid the flow during production. However, high moisture content in lactose can cause it to become sticky, forming hard clusters and complicating manufacturing processes. The USP specifies the acceptable water content range in lactose monohydrate between 4.5% and 5.5%.
Traditional methods for analyzing water content in lactose are time-consuming, which is why implementing a faster and more efficient method has become crucial.
The new method we present utilizes Near-Infrared Spectroscopy (NIRS), offering a quick, precise, and cost-effective way to determine water content in lactose. This method requires no reagents and provides results in just a few seconds.
Why Choose NIRS?
- Speed and efficiency: The method allows results to be obtained almost instantly, in just a few seconds.
- High precision: The predictive models are based on accurate spectroscopic data, ensuring precise analysis.
- No need for reagents: NIRS is a reagent-free method, eliminating the need for chemicals and reducing costs.
- Non-destructive analysis: The NIRS method is non-destructive, meaning the sample remains unchanged after analysis.
- Environmentally friendly: With no reagents used and minimal energy consumption, this method is eco-friendly.
Conclusion
This new method, using Near-Infrared Spectroscopy (NIRS) for determining water content in lactose, represents a significant advancement in the pharmaceutical industry. With its speed, precision, and cost-effectiveness, NIRS has become a reliable alternative to traditional methods, providing faster and easier solutions for moisture analysis in lactose.
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MPSlab d.o.o.
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E-mail: info@mpslab.ba